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The tin reagent and the iodo 4-dedimethylamino sancycline compound can be treated with a palladium catalyst (eg, Pd(PPh 3) 2Cl 2 or Pd(AsPh 3) 2Cl 2) and, optionally, with an additional copper salt, eg, CuI. There were no outliers (subjects with a decrease from baseline in standing systolic blood pressure of >30 mm Hg at one or more time points)?

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